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  • Evidence is increasing that most addiction without exception is related to issues with the brain's reward center, especially the mesolimbic system. This the main problem regulates reward responses in getting food and sex, plus in nurturing infants and children. One of the most important neurotransmitters associated with reward responses, both once they malfunction and after they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the amount of dopamine released in in response to a stimulus"(Bostwick & Bucci, 2008).

    Using two separate drugs to lose weight naturally can be very effective you will find combinations as you're watching FDA now awaiting approval. When dealing with weight-loss and the people that go through it you should err on the side of caution and let the FDA do its job and demand some research be done so the public understands the side effects and dangers of the medications before we bring them. Keep in mind that drug companies will be in business to generate money and that they would say anything to keep people on the medications.

    Researchers discovered that participants using this drug for any year, lost excess weight within a month and have kept the load off during the entire 56 weeks from the study. Contrave can be a combination in the drugs naltrexone and bupropion, which generally seems to reflect a new trend of weight-loss drugs which are made up of many active ingredient, that might make them more effective and safer.

    Combo-pilling will be the newest fad or also the newest ahead under scrutiny and thus it is just more publicly known although in the past, comb-pilling for weight reduction has been around since the eighties. The biggest reason that by using a combination of pills is starting to become popular could be the fact that since right now there aren't long term prescription slimming capsules that have been licensed by the FDA other than orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications however some of the combinations are actually rejected or have yet to be approved by the FDA.

    Seizures can be a side effect with Contrave and really should not be taken in people who have seizure disorders. The drug may also raise blood pressure and pulse rate, and must not be used in individuals with a history of heart attack or stroke in the last six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy while using drug.

    The FDA also warned that Contrave can raise hypertension and heartbeat and must not used in patients with uncontrolled high blood pressure, in addition to by you are not heart-related and cerebrovascular (circulation dysfunction impacting the mind) disease. Patients using a history of cardiac event or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes using a boxed warning to alert physicians and patients towards the increased chance of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for smoking cessation.

    Other people who must avoid using Contrave are patients experiencing bulimia, anorexia nervosa, anyone using opiods, and patients undergoing an 'abrupt discontinuation of alcohol, benzodiazepines, barbiturates and antiepileptic drugs.' Lastly Concave mustn't be prescribed for females who are pregnant or trying to become pregnant.

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