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The U.S. Food and Drug Administration has approved the application of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to help manage chronic obesity in adults with a body mass index (BMI) of greater than 27, given that they also have problems with weight-related health problems such as Tupe2 diabestes, high-cholesterol and/or hypertension (blood pressure).Contrave is really a combination of two FDA-approved drugs, naltrexone and bupropion, in the extended-release formulation. Naltrexone is approved to treat alcohol and opioid dependence. Bupropion is eligible to treat depression and seasonal affective disorder so that as an aid to stopping smoking treatment.'Obesity is still a major public health concern,' said Jean-Marc Guettier, M.D., director with the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination with a healthy lifestyle including a reduced-calorie dieting and exercise, Contrave provides another treatment choice for chronic weight management for people who are obese or are overweight and still have at least one weight-related health issue.'The drug's effectiveness was evaluated in multiple clinical trials that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for one year. All patients received lifestyle modification that consisted of a reduced- calorie diet and regular physical activity. Results from a clinical study that enrolled patients without diabetes indicated that patients had a typical weight loss of 4.1% instead of participants who were given placebos) during a 12- month period, while an outside study involving patients with diabetes had an average weight loss of 2% over treatment with placebo at one year.

Using two separate drugs to shed pounds can be very effective you can find combinations while watching FDA now awaiting approval. When dealing with weight loss and the individuals who go through it you ought to err assisting caution and permit the FDA do its job and demand some investigation be done so that the public recognizes the side effects and hazards of the medications before we bring them. Keep in mind that drug companies will be in business to make money and that they would say anything to keep people on their own medications.

Researchers discovered that participants investing in this drug for any year, dropped a few pounds within a month and have kept the load off through the entire 56 weeks in the study. Contrave can be a combination in the drugs naltrexone and bupropion, which appears to reflect a whole new trend of weight-loss drugs which can be made up of multiple active ingredient, which may make them more efficient and safer.

Combo-pilling may be the newest fad or in addition to this the newest ahead under scrutiny and so it is just more publicly known in recent months, comb-pilling for weight loss has been around since the eighties. The biggest reason that using a combination of pills is now popular will be the fact that at the time of right now there are no long term prescription weightloss pills that have been authorized by the FDA besides orlistat. The truly disturbing part is doctors are prescribing these combinations of medications even though some of the combinations are actually rejected or have yet to be licensed by the FDA.

Seizures can be a side effect with Contrave and really should not be taken in people with seizure disorders. The drug may also raise blood pressure levels and heartbeat, and must not be used in people with a history of cardiac event or stroke in the earlier six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy while using drug.

The FDA also warned that Contrave can raise hypertension and heartrate and must not used in patients with uncontrolled high blood pressure level, in addition to by anyone with heart-related and cerebrovascular (circulation system dysfunction impacting your brain) disease. Patients having a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes with a boxed warning to alert health care professionals and patients towards the increased probability of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for smoking cessation.

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